The Laboratory of Biomedical Imaging and Signal Processing at the University of Hong Kong pioneers ultra-low-field MRI technologies and preclinical neuroimaging research.
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The Laboratory of Biomedical Imaging and Signal Processing (BISP) is dedicated to developing magnetic resonance imaging (MRI) technologies to expand its utility in healthcare and advancing its applications for biomedical discovery. Under the direction of Prof. Ed X. Wu, our team combines cutting-edge engineering with computing strategies to push the boundaries of what is possible in biomedical imaging.
An article titled 'Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input' has been published in Nature Communications. This study demonstrates how a single thalamic input can rapidly trigger brain-wide network reconfigurations to support fast processing of sensory information.
An article titled 'Whole-body magnetic resonance imaging at 0.05 Tesla' has been published in Science. This study demonstrates the feasibility of whole-body MRI at ultra-low field strength, opening new possibilities for highly accessible, affordable, and safer medical imaging worldwide.
An article titled 'Deep learning enabled fast 3D brain MRI at 0.055 tesla' has been published in Science Advances. This study demonstrates a novel fast acquisition and deep learning reconstruction framework that accelerates high-quality whole-brain MRI at ultra-low field strength.
An article titled 'A low-cost and shielding-free ultra-low-field brain MRI scanner' has been published in Nature Communications. This study demonstrates the technical and clinical feasibility of a compact, affordable 0.055 Tesla brain MRI scanner that operates without the need for magnetic or radiofrequency shielding cages.
An article titled 'Functional MRI reveals brain-wide actions on thalamically-initiated oscillatory activities on associate memory consolidation' has been published in Nature Communications. This study demonstrates how specific oscillatory activities initiated in the thalamus influence widespread functional networks critical for the consolidation of associative memory.
An article titled 'Optogenetic fMRI interrogation of brain-wide vestibular pathways' has been published in the Proceedings of the National Academy of Sciences. By combining optogenetics with functional MRI, this research maps and interrogates complex vestibular networks, offering unprecedented insights into how the brain processes spatial orientation and balance.
An article titled 'Low-frequency hippocampal-cortical activity drives brain-wide resting-state functional MRI connectivity' has been published in the Proceedings of the National Academy of Sciences. This pivotal study reveals that low-frequency neural signals originating in the hippocampus act as fundamental drivers of large-scale, resting-state cortical connectivity.
An article titled 'Long-range projections coordinate distributed brainwide neural activity with a specific spatiotemporal profile' has been published in the Proceedings of the National Academy of Sciences. This foundational research unveils how long-range neural projections synchronize widespread brain activity, governing the spatiotemporal dynamics of large-scale functional networks.
Phone: +852 3917 9713
Fax: +852 3917 9711
Email:
ewu1@hku.hk /
ewu@eee.hku.hk
Department of Electrical and Computer Engineering
Faculty of Engineering
The University of Hong Kong
Pokfulam, Hong Kong