Research

Magnetic Resonance Spectroscopy Imaging

Extramyocellular Lipid (EMCL) & Intramyocellular Lipid (IMCL) Diffusion-Weighted MRS

Rodent Brain MRS

Illustration of the voxel placement over the left and right visual cortex for 1H MRS in a Sprague-Dawley rat 3 weeks after the right monocular enucleation (ME) (right eye removal) at postnatal day 10. Abbreviation: L, left; R, right; A, anterior; P, posterior.

Typical 1H MR spectra obtained on each side of the visual cortex in rats at 3 weeks after right ME. Note the lower Tau signal in the left visual cortex (contralateral to enucleated eye). Spectra similar to that shown for the right visual cortex were observed for normal intact animals. Abbreviations: Lac, lactate; NAA, N-acetylaspartate; Glu, glutamate; Cr, creatine; Cho, choline; Tau, taurine; m-Ins, myo-inositol.

Liver MRS

(a) Illustration of the voxel placement (solid-line box) in the adult rat liver for proton magnetic resonance spectroscopy (1H MRS) at 7 Tesla. (b) Typical liver 1H MRS spectra from the same animal at 1 day before, 6 hours, 1 day, and 1 week after 30 minutes hepatic ischemia/reperfusion injury (IRI). Animals at 6 hours after hepatic IRI consistently showed markedly increased CCC and Glyu level. -CH3: methyl proton; (-CH2-)n: methylene proton; -CH=CH-CH2-: allylic proton; Glx: glutamine and glutamate complex; =CH-CH2-CH=: diallylic proton; CCC: choline-containing compounds; Glyu: glycogen and glucose complex; -CH=CH-: methene proton.