**Research**

**
Molecular
Imaging**

__Manganese-Enhanced MRI__

__Liver Fibrosis__

Typical T_{1}- and T_{2}-weighted images, T_{1}
and T_{2} maps from one animal at 0 and 4 weeks after CCl_{4}
insult. Typical measurement ROIs are shown in T_{1} and T_{2}
maps.

__Microbubbles__

(a) Representative light microscopy of MION-entrapped PMBs. (b) Histogram showing diameter distribution for a representative batch of MION-entrapped PMBs. The mean diameter of MION-entrapped PMBs is 9.77 μm.

The typical multiecho GE signals from a MION-free PMB phantom
(5% volume fraction) in (a) its initial well-suspended state and (b) its final
microbubble-free state with the monoexponential fitting in dotted lines. c: R_{2}*
vs time. The multiecho GE signals from a MION-entrapped PMB phantom (5% volume
fraction) in (d) its initial well-suspended state and (e) its final
microbubble-free state. f: R_{2}* vs time.